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Hypogonadism - Definition, Causes, Symptoms and Treatment

Hypogonadism is a medical term for asymptoms similar to those of menopause
defect of the reproductive system whichin women. These may include hot flashes,
results in lack of function of thedecreased drive, irritability,
gonads (ovaries or testes). Hypogonadismdepression and fatigue.
may occur if theHypogonadism is most often treated by
hypothalamic-pituitary-gonadal axis isreplacement of the appropriate hormones.
interrupted at any level.Gonadotropin or GnRH replacement is
Hypergonadotropic hypogonadism (primaryoffered to the patient when fertility is
hypogonadism) results if the gonad doesdesired. Oral testosterone is no longer
not produce the amount of steroidused in the U.S. because it is broken
sufficient to suppress secretion of LHdown in the liver and rendered inactive.
and FSH at normal levels. HypogonadismIn boys, testosterone replacement
resulting from defects of the gonads istherapy (TRT) can stimulate puberty and
traditionally referred to as primarythe development of secondary
hypogonadism. Examples includecharacteristics, such as increased
Klinefelter syndrome and Turnermuscle mass, beard and pubic hair
syndrome. Hypogonadism resulting fromgrowth. Also available is a topical 1%
hypothalamic or pituitary defects aretestosterone gel. It is applied once
termed secondary hypogonadism or centraldaily to clean, dry skin of the
hypogonadism (referring to the centralshoulders, upper arms, or abdomen.
nervous system). Hypogonadism can affectAnother alternative is testosterone
men of any age, from fetal development,patches. The testosterone may be mixed
through puberty and adulthood.with the adhesive with a new patch
Hypogonadism is one of the main causesapplied daily to a different site; this
of male infertility. It is estimatedsystem leaves a sticky residue but
that 13 million men in the United Statescauses little skin irritation.
alone are affected by hypogonadism.Injections of pituitary hormone may be
Hypogonadism is caused by deficientused to help male patients produce
testosterone secretion by the testes.sperm. In others, surgery and radiation
The two basic types of male hypogonadismtherapy may be needed. In adult men, TRT
are Primary and Secondary.can restore function and muscle strength
Hypogonadism Primary, also known asand prevent bone loss.
primary testicular failure, originatesTreatment for Hypogonadism Tips
from an abnormality in the testicles.1. Hormone-based medicines are available
Hypogonadism may be induced by chronicfor men and women.
use of anabolic/androgenic steroids2. Estrogen comes in the form of a patch
(AAS). The Secondary type ofor pill.
hypogonadism is caused by defects in the3. Testosterone can be given by using a
pituitary gland connected to the brainpatch Injections of pituitary hormone
that controls hormone production. Ifmay be used to help male patients
chemical messages from the pituitaryproduce sperm.
gland to the testicles aren't sent,4. Topical 1% testosterone gel. It is
impaired testicular function occurs.applied once daily to clean, dry skin of
This condition can be a result fromthe shoulders, upper arms, or abdomen.
defects in development of the pituitary5. Tumors can be treated with surgery
gland, certain inflammatory diseases,and radiotherapy.
and the use of certain drugs used in the6. In boys, testosterone replacement
treatment of psychiatric disorders andtherapy (TRT) can stimulate puberty and
gastroesophageal reflux disease. Mentalthe development of secondary
and emotional changes can also accompanycharacteristics, such as increased
hypogonadism. As testosterone decreases,muscle mass, beard and pubic hair
some men may experience signs andgrowth.



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