| The application of bio systems in the development of | | | | number of computer-based primer design algorithms |
| gene tools has proven efficacy for altered methylation | | | | are available to researchers interested in determining |
| patterns that develop genetic disorders, cancer and | | | | the aging process from the approach of DNA for |
| aging. Primer design studies has shown changes | | | | mapping chromatin domains, while reducing |
| occurring in DNA used as molecular markers of cell | | | | costs.Research lead by the National Institute of Aging |
| degradation mechanisms leading to disease or | | | | (NIA) found that defective WRNp protein is involved in |
| changes in tissue structure and function.Real time PCR | | | | premature aging disorder, helping scientist to |
| is a reliable and easy to use technique to detect and | | | | understand primer design analysis toward DNA repair, |
| measure DNA methylation by direct monitoring of a | | | | which becomes less efficient during normal human |
| PCR reaction useful for both research and routine | | | | aging. The NIA is one of the 25 institutes of the |
| diagnostics. Because aging is the result of general | | | | National Institutes of Health, leading the Federal effort in |
| deterioration of the body's cells increasing with age, | | | | supporting research on aging.Gene Tools, including Real |
| primer design analysis can help to determine | | | | time PCR, are powerful identifiers of gene expression |
| contributing factors to delay the process.New gene | | | | patterns modifying DNA that eventually contribute to |
| tools are the response to genomics-based approach | | | | develop aging-related diseases such as Parkinson |
| to human genetics proposed in the 1990's, however, | | | | disease, Alzheimer's disease and the |
| aging treatments based on the study and capture of | | | | Hutchinson-Gilford progeria syndrome (HGPS) referred |
| the human DNA sequence variations information are | | | | to as a premature aging syndrome.Copyright @2006, |
| not financially feasible yet. However, by lowering the | | | | 4th Media CorporationYou have permission to publish |
| costs of real time PCR will increase the power of | | | | this article electronically free of charge, as long as the |
| gene tools to identify the origin of cells aging.Stacey | | | | bylines and links in the body of the article and the |
| Gabriel, director of the Broad Institute's Genetic | | | | bylines are included.Natalie Aranda writes about health, |
| Analysis said, "when we started doing this work a | | | | skin care and fitness. The application of bio systems in |
| number of years ago, determining the genotype of a | | | | the development of gene tools has proven efficacy |
| SNP in a patient cost nearly a dollar, and we could do | | | | for altered methylation patterns that develop genetic |
| hundreds a day. Today the prices have dropped in | | | | disorders, cancer and aging. Primer design studies has |
| many cases to a fraction of a penny per genotype, | | | | shown changes occurring in DNA used as molecular |
| and we can do millions a day. This is the difference | | | | markers of cell degradation mechanisms leading to |
| between not being able to do the studies, and getting | | | | disease or changes in tissue structure and function. |
| them done rapidly and well."Primer design is the initial | | | | Real time PCR is a reliable and easy to use technique |
| element required to set an anti-aging methodology | | | | to detect and measure DNA methylation by direct |
| based on gene structure, hence allowing improved | | | | monitoring of a PCR reaction useful for both research |
| automation of real time PCR. In addition, a large | | | | and routine diagnostics. |